七特斯拉磁共振波谱成像与三特斯拉磁共振指纹技术在胶质瘤患者肿瘤定位方面的比较
摘要：磁共振波谱成像（MRSI）和磁共振指纹（MRF）在胶质瘤患者中的相关性的研究：采用从MRSI获得的神经肿瘤标志物与从MRF获得的T1/T2图进行对比分析了12名胶质瘤患者的数据。通过定义T1、T2和各种代谢比率的热点，并使用S{o}rensen-Dice相似系数（DSC）和它们的强度中心（COIDs）之间的距离进行比较。MRF与肿瘤分割之间的中位DSC为0.73（T1）和0.79（T2）。MRSI与MRF之间的DSC最高为Gln/tNAA（T1:0.75，T2:0.80，肿瘤:0.78），其次为Gly/tNAA（T1:0.57，T2:0.62，肿瘤:0.54）和tCho/tNAA（T1:0.61，T2:0.58，肿瘤:0.45）。肿瘤热点区域的中位值为T1=1724ms，T2=86ms，Gln/tNAA=0.61，Gly/tNAA=0.28，Ins/tNAA=1.15和tCho/tNAA=0.48，在肿瘤周围区域，中位值为T1=1756ms，T2=102ms，Gln/tNAA=0.38，Gly/tNAA=0.20，Ins/tNAA=1.06和tCho/tNAA=0.38，在常规白质中，中位值为T1=950ms，T2=43ms，Gln/tNAA=0.16，Gly/tNAA=0.07，Ins/tNAA=0.54和tCho/tNAA=0.20。这项研究的结果是首次对比7T MRSI和3T MRF，表明这些方法之间具有良好的一致性。
作者：Philipp Lazen (1,2,3), Pedro Lima Cardoso (1), Sukrit Sharma (1), Cornelius Cadrien (1,2), Thomas Roetzer-Pejrimovsky (4), Julia Furtner (5,6), Bernhard Strasser (1), Lukas Hingerl (1), Alexandra Lipka (1), Matthias Preusser (7), Wolfgang Marik (5), Wolfgang Bogner (1,3), Georg Widhalm (2), Karl R"ossler (2,3), Siegfried Trattnig (1,3,8), Gilbert Hangel (1,2,3) ((1) High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, (2) Department for Neurosurgery, Medical University of Vienna, Vienna, Austria, (3) Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, (4) Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria, (5) Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, (6) Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Danube Private University, Krems, Austria, (7) Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, (8) Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. P"olten, Austria)
论文ID：2304.05254
分类：Medical Physics
分类简称：physics.med-ph
提交时间：2023-04-12