流感A、B型M2和中东呼吸综合征(MERS)、严重急性呼吸综合征(SARS-CoV) E病毒蛋白的跨膜肽的折叠分子动力学模拟
摘要：Viroporins are small viral proteins that induce the formation of hydrophilic pores in host cell membranes. This study compares the folding of transmembrane peptides from viroporins derived from influenza A, influenza B, MERS-Cov-2, and SARS-CoV-2 viruses. Molecular dynamics simulations reveal differences in peptide sequence and secondary structure between the influenza and coronavirus peptides. The influenza peptides have a more stable N-terminal half and a fast converting C-terminal half, while the coronavirus peptides are more stable and fast helix formers. These findings provide insights into the structural characteristics of viroporins.
作者：Antonios Kolocouris, Isaiah Arkin and Nicholas M. Glykos
论文ID：2209.05377
分类：Biomolecules
分类简称：q-bio.BM
提交时间：2022-09-13