旧蛋白质的新视角：澄清神秘的蛋白质组
摘要：人类所有的疾病都涉及蛋白质，然而我们目前用于表征和定量蛋白质的工具是有限的。为了更好地阐明蛋白质在空间、时间和分子组成上的特性，我们提供了有关技术的挑战以及蛋白质生物学所面临挑战的引人瞩目的预测。通过广泛的视角，我们讨论了将蛋白质组学科学转化为更有推动力的事业的重大机遇。通过推断最近的趋势，我们提供了潜在的未来理论，以定义、量化和可视化蛋白质组的多个维度，从而在未来十年内改变我们对人类疾病的认识和相互作用。
作者：Participants in a NIH Workshop on Functional and Integrative Proteomics: Kristin E. Burnum Johnson (1), Thomas P. Conrads (2), Richard R. Drake (3), Amy E. Herr (4), Ravi Iyengar (5), Ryan T. Kelly (6), Emma Lundberg (7), Michael J. MacCoss (8), Alexandra Naba (9), Garry P. Nolan (10), Pavel A. Pevzner (11), Karin D. Rodland (12), Salvatore Sechi (13), Nikolai Slavov (14), Jeffrey M. Spraggins (15), Jennifer E. Van Eyk (16), Marc Vidal (17), Christine Vogel (18), David R. Walt (19), Neil L. Kelleher (20) ((1) Pacific Northwest National Laboratory, (2) Inova Health System, (3) Medical University of South Carolina, (4) University of California, Berkeley, (5) Icahn School of Medicine at Mount Sinai, (6) Brigham Young University, (7) KTH Royal Institute of Technology, (8) University of Washington, (9) University of Illinois at Chicago, (10) Stanford University, (11) University of California at San Diego, (12) Pacific Northwest National Laboratory, (13) National Institutes of Health, (14) Northeastern University, (15) Vanderbilt University, (16) Cedars Sinai Medical Center, (17) Harvard University, (18) New York University, (19) Harvard Medical School, (20) Northwestern University)
论文ID：2108.07660
分类：Biomolecules
分类简称：q-bio.BM
提交时间：2021-08-18